ANALYSIS OF AMB-FUBINACA BIOTRANSFORMATION PATHWAYS IN HUMAN LIVER MICROSOME AND ZEBRAFISH SYSTEMS BY LIQUID CHROMATOGRAPHY-HIGH RESOLUTION MASS SPECTROMETRY

In this study, the metabolic profiles of a new illicit drug AMB-FUBINACA were investigated using both human liver microsome and zebrafish Comic Supplies models.Liquid chromatography Q Extractive HF Hybrid Quadrupole-Orbitrap mass spectrometry (LC-QE-HF-MS) was employed to analyze the metabolic sites and pathways.AMB-FUBINACA was added to the in vit

Children with complex needs often have limited communication which makes clinical assessment extremely difficult.They also require complex feeding regimes and are prone to chronic bowel dysfunction and dysmotility requiring frequent admissions to hospital.We present the case of an 11-year old boy with mosaic trisomy 13 and an end ileostomy (for gut

Spermatogonial stem cells (SSCs) sustain and modulate spermatogenesis through intricate signaling pathways and transcription factors.Promyelocytic leukemia zinc-finger (Plzf, also known as Zbtb16) has been identified as a critical transcription factor influencing various signaling and differentiation pathways.Plzf plays a pivotal role in regulating

Persistent Scatterer InSAR (PS-InSAR) technology enables the monitoring of displacement in millimeters.However, without the use of external parameter correction, radar scatterers exhibit poor geopositioning precision in meters, limiting the correlation between observed deformation and the actual structure.The integration of PS-InSAR datasets Decora

Abstract Extensive research on the multi-bridge extension of cascaded rectifier stages is deemed important to meet the requirements of high-voltage and high-power applications.Two control structures for capacitor voltage balancing in cascaded rectifier stages are analyzed in this paper.On 329 this basis, the balance strategy for the multi-bridge ex